Biohub for Non-Biologists: Behind Priscilla Chan and Mark Zuckerberg's plan to cure all diseases

The CZI has acquired EvoScale, established the first 10,000 GPU cluster for bio research, open sourced the largest atlas of human cell types, and gone…

13 hrs ago • 

swyx (Shawn)

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3

October 2025

Agentic Commerce Protocol and building the Economic Infrastructure for AI — with Emily Glassberg Sands, Head of Data & AI at Stripe

How Stripe built a payments foundation model, why stablecoins are powering more of the AI economy, and growing internal AI adoption to 8,500 employees…

Oct 30

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Developers as the distribution layer of AGI (OpenAI Dev Day 2025, ft. Sherwin Wu and Christina Huang)

A quick recap of the 2025 OpenAI DevDay coupled with an exclusive interview with the OpenAI Platform team that shipped AgentKit and related products!

Oct 7

26

1

Taste is your moat — with Dylan Field, Figma

Letting designers build with Figma Make, how Figma can be the context repository for aesthetic in the age of vibe coding, and why design is your only…

Oct 2

31

3

September 2025

How GPT5 + Codex took over Agentic Coding — ft. Greg Brockman, OpenAI

Belated catchup on our podcast with Greg Brockman, + latest takes on the new GPT-5-Codex model

Sep 16

51

5

A Technical History of Generative Media — with Gorkem and Batuhan from Fal.ai

From Stable Diffusion to Veo3, why generative media is completely different than LLM inference, and how to scale to $100M ARR while writing custom…

Sep 5

31

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August 2025

"RAG is Dead, Context Engineering is King" — with Jeff Huber of Chroma

What actually matters in vector databases in 2025, why “modern search for AI” is different, and how to ship systems that don’t rot as context grows.

Aug 19

94

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7

Can coding agents self-improve?

Can GPT-5 build better dev tools for itself? Does it improve its coding performance?

Aug 9 • 

Alessio Fanelli

76

7

5

GPT-5's Vision Checkup: a frontier VLM, but not a new SOTA

Our friends at Roboflow ran the numbers today on GPT-5's underrated (but also improved) vision capabilities.

Aug 7 • 

Matvei Popov

42

GPT-5's Router: how it works and why Frontier Labs are now targeting the Pareto Frontier

The big reveal of GPT-5 was entirely unexpected but is welcome nonetheless - there's a router!

Aug 7

60

7

GPT-5 Hands-On: Welcome to the Stone Age

We're excited to publish our hands-on review from the developer beta.

Aug 7 • 

alexis

, 

Ben Hylak

, and 

Latent.Space

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July 2025

Cline: The Open Source Code Agent — with Saoud Rizwan and Nik Pash

On the heels of their $32m Series A: Why fast apply models got bitter lesson'd, pioneering the plan + act paradigm for coding, and why people are use…

Jul 31

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